Implementation of Lean Six Sigma has become common practice in many levels of business, and it produces efficient and positive outcomes. Over the past two decades, many healthcare systems have been adopting adequate business strategies and implementing them into their respective healthcare facilities. While common and effective for most other industries, Lean Six Sigma has only recently taken over healthcare. Lean Six Sigma has remarkably amended the healthcare system by improving the quality of care for patients and providing healthcare facilities with several cost-effective solutions. Examples of implementing Lean Six Sigma on an entire healthcare system as well as on a departmental level are highlighted in this paper.