Prioritizing and increasing access to effective suicide prevention efforts in clinical care is imperative to reducing the number of American lives lost each year to suicide. The need for more effective suicide prevention efforts is critically urgent and must be thoroughly examined, researched, and implemented. A comprehensive approach to suicide prevention in the clinical realm will require a systematic understanding of the barriers that hinder suicide prevention, how to identify those at risk, and effective intervention strategies for suicidal patients. Although research has sought to identify evidence- based interventions for suicide prevention, there still remains little cohesion and standardization in the medical field for producing and sustaining reductions in suicide. Due to the interconnectedness between healthcare providers, effective mental health treatment, and ultimately, potential suicide preventions, there is an essential responsibility that exists for healthcare leaders to improve current practices. A methodical literature review was conducted through an analysis of public health recommendations, surveys, studies, and quantitative data reports. The findings will show the staggering suicide statistics in the United States, which emphasizes the need for immediate action, as well as the disparity that exists between detectable and treatable conditions and successful suicide prevention. The literature will reveal that supporting suicide prevention in clinical settings is a multifaceted and complex initiative but can be achieved through the collective implementation of evidence-based practices, greater comprehensive training for providers, and continued research that addresses contributing factors and treatments for suicidality.